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gli-2 proto-oncogene protein; zinc finger protein GLI2; tax helper protein (GLI2, THP)

Function: - may play a role during embryogenesis - binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the TRE-2S regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1 - implicated in the transduction of SHH signal Structure: - belongs to the GLI C2H2-type Zn+2-finger protein family - contains 5 C2H2-type Zn+2 fingers Compartment: nucleus (putative) Alternative splicing: named isoforms=4 Pathology: - defects in GLI2 are the cause of holoprosencephaly type 9

Related

gli-2 proto-oncogene

General

C2H2 type zinc finger protein GLI-Krueppel family protein

Properties

SIZE: entity length = 1258 aa MW = 133 kD COMPARTMENT: cell nucleus MOTIF: Zn finger C2H2-type SITE: 109-134 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 142-169 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 175-199 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 205-230 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 236-261 EFFECTOR-BOUND: Zn+2

References

  1. UniProt :accession P10070
  2. Entrez Gene :accession 2736
  3. UniProt :accession P10070

Databases & Figures

OMIM 165230 UniProt P10070 Pfam PF00096 Entrez Gene 2736 Kegg hsa:2736 hedgehog/gli pathway