gliomedin (cancer-related gene liver-2 protein, GLDN, COLM, UNQ9339/PRO34011)

Function: 1) role in formation of nodes of Ranvier along myelinated axons 3) NRCAM & NFASC (neurofascin) ligand (probable) - binding via olfactomedin-like domain 4) glial positional clue required for molecular assembly of nodes of Ranvier (putative) Structure: - contains 2 collagen-like domains - contains 1 olfactomedin-like domain Compartment: cell membrane, localizes to the nodes of Ranvier Alternative splicing: named isoforms=2 Expression: - expressed in spinal cord, brain, placenta, sciatic nerve - more abundant in peripheral than central nervous system

General

glycoprotein membrane protein

Properties

SIZE: MW = 59 kD entity length = 551 aa COMPARTMENT: cellular membrane MOTIF: transmembrane domain {18-39} N-glycosylation site {N130} Collagen-like 1 {137-195} Collagen-like 2 {196-222} proline-rich region SITE: 237-264 MOTIF: proline residue (SEVERAL) Olfactomedin-like {299-546} MOTIF: N-glycosylation site {N329} N-glycosylation site {N357} N-glycosylation site {N378} N-glycosylation site {N464}

Database Correlations

OMIM 608603 UniProt Q6ZMI3 PFAM correlations

References

UniProt :accession Q6ZMI3