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germ cell neoplasm
Epidemiology:
- account for ~30% of ovarian tumors
- incidence ratio of whites:blacks is ~ 5:1 (USA)
Genetics:
- implicated genes:
- ALPPL2, KIT, BCL10
Clinical manifestations:
- 95% of GCTs occur in the gonads, the rest occur in extragonadal tissues (see extragonadal germ cell neoplasm)
Laboratory:
1) alpha-fetoprotein may be secreted
2) chorionic gonadotropin may be secreted
Specific
choriocarcinoma
embryonal carcinoma
extragonadal germ cell neoplasm
germinoma
gonadoblastoma
teratoma; dermoid
yolk sac tumor; endodermal sinus tumor
General
neoplasm; tumor
Database Correlations
OMIM 273300
References
- Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed)
Lippincott-Raven, Philadelphia, 1998, pg 667
- Anonymous
International Germ Cell Consensus Classification:
a prognostic factor-based staging system for metastatic germ
cell cancers. International Germ Cell Cancer Collaborative Group.
J Clin Oncol. 1997 Feb;15(2):594-603.
PMID: 9053482
- National Cancer Institute
Extragonadal Germ Cell Tumors Tumors Treatment (PDQ) - Health Professional Version
https://www.cancer.gov/types/extragonadal-germ-cell/hp/extragonadal-treatment-pdq