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genomic approach in cancer treatment
Procedure:
- complete sequencing of entire genome of normal & malignant cells
- analysis of RNA expression of normal & malignant cells
- examination of differences [1]
Notes:
- technique applied to case of adult ALL where lymphocytes, normal & malignant could presumably be isolated & cultured
- malignant lymphocytes apparently overexpressed FLT3 which was treated with sunitinib (Sutent) [1]
Related
malignant neoplasm (cancer)
General
cancer treatment
References
- Kolata G
Genetic Gamble: New Approaches to Fighting Cancer
http://www.nytimes.com/2012/07/08/health/in-gene-sequencing-treatment-for-leukemia-glimpses-of-the-future.html
- Brooks M
Online Tool IDs People With Genetic Mutations Linked to Cancer.
Medscape. August 30, 2022
https://www.medscape.com/viewarticle/979965
- Yurgelun MB, Uno H, Furniss CS et al
Development and Validation of the PREMMplus Model for Multigene
Hereditary Cancer Risk Assessment.
J Clin Oncol. 2022. August 12
PMID: 35960913
https://ascopubs.org/doi/abs/10.1200/jco.22.00120