general transcription factor 3C polypeptide 1; TF3C-alpha; TFIIIC box B-binding subunit; transcription factor IIIC 220 kD subunit; TFIIIC 220 kD subunit; TFIIIC220; transcription factor IIIC subunit alpha (GTF3C1)

Function: - required for RNA polymerase 3-mediated transcription - component of TFIIIC that initiates transcription complex assembly on tRNA & is required for transcription of 5S rRNA & other stable nuclear & cytoplasmic RNAs - binds to the box B promoter element - part of the TFIIIC subcomplex TFIIIC2 - phosphorylated upon DNA damage, probably by ATM or ATR Structure: belongs to the TFIIIC subunit 1 family Compartment: nucleus Alternative splicing: named isoforms=3

General

nuclear protein phosphoprotein protein subunit

Properties

SIZE: entity length = 2109 aa MW = 239 kD COMPARTMENT: cell nucleus MOTIF: acidic region {343-351} MOTIF: acidic residue (SEVERAL) Ser phosphorylation site {S739} Ser phosphorylation site {S751} Thr phosphorylation site {T774} Ser phosphorylation site {S1062} Thr phosphorylation site {T1064} Ser phosphorylation site {S1068} lysine-rich region {1205-1233} MOTIF: lysine residue (SEVERAL) Ser phosphorylation site {S1611} acidic region {1613-1624} MOTIF: acidic residue (SEVERAL) Ser phosphorylation site {S1632} Ser phosphorylation site {S1653} Ser phosphorylation site {S1856} Ser phosphorylation site {S1865} Ser phosphorylation site {S1868} Ser phosphorylation site {S1969}

Database Correlations

OMIM 603246 UniProt Q12789 Pfam PF04182 Entrez Gene 2975 Kegg hsa:2975

References

UniProt :accession Q12789