GDP-L-fucose synthetase (protein FX, red cell NADPH-binding protein, GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase, tissue-specific transplantation antigen 3, TSTA3)

Function: - 2 step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase & a reductase reaction - carbohydrate biosynthesis; GDP-L-fucose biosynthesis via de novo pathway GDP-L-fucose from GDP-D-mannose, step 2 [final step] GDP-L-fucose + NADP+ GDP-4-dehydro-6-deoxy-D-mannose + NADPH Structure: 1) homodimer 2) belongs to the fucose synthetase family

General

epimerase oxidoreductase

Properties

SIZE: MW = 36 kD entity length = 321 aa MOTIF: cofactor-binding site [9-39] COFACTOR-BOUND: NAD

Database Correlations

OMIM 137020 UniProt Q13630 Pfam PF01370 ENZYME 1.1.1.271

References

UniProt :accession Q13630