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GDP-fucose protein O-fucosyltransferase 2 (peptide-O-fucosyltransferase 2, O-FucT-2, POFUT2, C21orf80, FUT13, KIAA0958)

Function: 1) glycosylation 2) catalyzes reaction that attaches fucose through an O-glycosidic linkage to a conserved Ser or Thr in thrombospondin type-1 repeats 3) transfers an alpha-L-fucosyl residue from GDP- beta-L-fucose to the Ser hydroxy group of a protein acceptor Structure: belongs to the glycosyltransferase 68 family Compartment: endoplasmic reticulum Alternative splicing: named isoforms=3 Expression: - isoform A is expressed in fetal liver & peripheral blood lymphocytes - isoform B is expressed in spleen, lung, testis, bone marrow, thymus, pancreas, prostate, fetal brain, fetal liver & fetal kidney - isoform C is expressed in brain, heart, spleen, liver, lung, stomach, testis, placenta, skin, thymus, pancreas, mammary gland, prostate, fetal brain, fetal liver & fetal heart

General

glycoprotein glycosyltransferase

Properties

SIZE: MW = 50 kD entity length = 429 aa COMPARTMENT: endoplasmic reticulum MOTIF: signal sequence {1-21} N-glycosylation site {N189} N-glycosylation site {N209} N-glycosylation site {N259}

Database Correlations

UniProt Q9Y2G5 ENZYME 2.4.1.221

References

  1. UniProt :accession Q9Y2G5
  2. GlycoGene database http://ggdb.muse.aist.go.jp/GGDB/index.jsp