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GDP-fucose protein O-fucosyltransferase 1; peptide-O-fucosyltransferase 1; O-fucT-1 (POFUT1, FUT12, KIAA0180)
Function:
1) attaches fucose through O-glycosidic linkage to conserved Ser or Thr in EGF domains
- transfers an alpha-L-fucosyl residue from GDP-beta-L-fucose
2) role in Notch signaling.
Cofactor: Mn+2
Structure:
- N-glycosylated
- belongs to the glycosyltransferase 68 family
Compartment: endoplasmic reticulum
Alternative splicing: named isoforms=2
Expression:
- expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas
General
fucosyltransferase
glycoprotein
Properties
SIZE: entity length = 388 aa
MW = 44 kD
COMPARTMENT: endoplasmic reticulum
MOTIF: signal sequence {1-26}
N-glycosylation site {N62}
N-glycosylation site {N160}
Prevents secretion from ER {385-388}
Database Correlations
OMIM 607491
UniProt Q9H488
Pfam PF10250
Entrez Gene 23509
Kegg hsa:23509
ENZYME 2.4.1.221
References
- UniProt :accession Q9H488
- GGDB; Note: glycogene database
http://riodb.ibase.aist.go.jp/rcmg/ggdb/
- Functional glycomics gateway - GTase
Note: peptide-O-fucosyltransferase 1
http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewglycoEnzyme.jsp?gbpId=gt_hum_609