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GDC-0449
Indications:
- rare cases of locally invasive or metastatic basal cell carcinoma (experimental) [1]
Dosage:
- 150-540 mg PO QD
Mechanism of action:
- interferes with hedgehog/gli pathway
General
antineoplastic agent (chemotherapeutic agent)
Figures/Diagrams
hedgehog/gli pathway
References
- Von Hoff DD et al
Inhibition of the hedgehog pathway in advanced basal-cell
carcinoma.
N Engl J Med 2009 Sep 2
PMID: 19726763
http://dx.doi.org/10.1056/NEJMoa05360
- Dlugosz AA and Talpaz M.
Following the hedgehog to new cancer therapies.
N Engl J Med 2009 Sep 2
PMID: 19726764
http://dx.doi.org/10.1056/NEJMe0906092