Search
GCN-4
Function:
- yeast transcription factor
- human ortholog is ATF4
- may upregulate expression of genes involved in the unfolded protein response pathway
General
DNA-binding protein
fungus-specific molecule
transcription factor (TF)
Properties
COMPARTMENT: cellular compartment
CELL: yeast
KINGDOM: plant
DIVISION: EUMYCOPHYTA
MOTIF: basic helix-loop-helix
MOTIF: basic DNA-binding motif
helix-loop-helix
NAME: helix-loop-helix
FOR-BINDING-VIA: helix-loop-helix
FOR-BINDING-OF: DNA motif
FOR-BINDING-VIA: helix-loop-helix
leucine zipper
FOR-BINDING-VIA: leucine zipper
References
- Kouzarides T, Ziff E.
The role of the leucine zipper in the fos-jun interaction.
Nature. 1988 Dec 15;336(6200):646-51.
PMID: 2974122
- Dwarki VJ, Montminy M, Verma IM.
Both the basic region and the 'leucine zipper' domain of
the cyclic AMP response element binding (CREB) protein are
essential for transcriptional activation.
EMBO J. 1990 Jan;9(1):225-32.
PMID: 2136830