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GA-binding protein
Function:
- transcription factor capable of interacting with purine rich repeats (GA repeats)
- necessary for the expression of the adenovirus E4 gene
Structure:
- heterotetramer of two alpha & two beta subunits
General
multisubunit protein
transcription factor (TF)
Properties
COMPARTMENT: cell nucleus
SUBUNITS: GA-binding protein-alpha
MOTIF: PNT {170-251}
ETS domain
NAME: ETS domain
SITE: 320-400
GA-binding protein-beta 1
MOTIF: ankyrin repeat
NAME: ankyrin repeat
SITE: 5-34
ankyrin repeat
NAME: ankyrin repeat
SITE: 37-66
ankyrin repeat
NAME: ankyrin repeat
SITE: 70-99
ankyrin repeat
NAME: ankyrin repeat
SITE: 103-132
ankyrin repeat
NAME: ankyrin repeat
SITE: 136-166
transcriptional activation domain
SITE: 258-327
References
- Macleod K, Leprince D, Stehelin D.
The ets gene family.
Trends Biochem Sci. 1992 Jul;17(7):251-6. Review.
PMID: 1502727
Components
GA-binding protein transcription factor alpha; nuclear respiratory factor 2 alpha subunit; GABP subunit alpha; transcription factor E4TF1-60 (GABPA, E4TF1A)
GA-binding protein transcription factor beta 1; GABP subunit beta-1; GABPB-1; GABP subunit beta-2; GABPB-2; transcription factor E4TF1-53; transcription factor E4TF1-47; nuclear respiratory factor 2 (GABPB1, E4TF1B, GABPB, GABPB2)