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gastrokine-1; 18 kD antrum mucosa protein; AMP-18; protein CA11 (GKN1, AMP18, CA11, UNQ489/PRO1005)
Function:
1) mitogenic activity
2) maintenance of gastric mucosal epithelium
Structure:
- belongs to the gastrokine family,
- contains 1 BRICHOS domain
Compartment: secreted
Expression:
- expressed in stomach
- no expression in gastric cancer tissue or gastric cancer cell lines
Notes:
- uncertain whether Met-1 or Met-15 is the initiator
Related
gastrokine-2 (blottin, Trefoil factor interactions(z) 1, down-regulated in gastric cancer, GKN2, BLOT, GDDR, TFIZ1, UNQ465/PRO813)
General
secreted protein
Properties
SIZE: entity length = 199 aa
MW = 22 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-34}
BRICHOS {68-164}
MOTIF: cysteine residue {C95}
MODIFICATION: cysteine residue {C156}
cysteine residue {C156}
MODIFICATION: cysteine residue {C95}
Database Correlations
OMIM 606402
UniProt Q9NS71
Pfam PF04089
Entrez Gene 56287
Kegg hsa:56287
References
UniProt :accession Q9NS71