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gastrin-releasing peptide receptor; GRP-R; GRP-preferring bombesin receptor (GRPR)
Function:
- receptor for gastrin releasing peptide (GRP)
- mediates its action by association with G proteins that activate a phosphatidylinositol-Ca+2 second messenger system
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- highly expressed in pancreas
- also expressed in stomach, adrenal cortex & brain
Related
gastrin-releasing peptide; contains: neuromedin-C; GRP-10 (GRP)
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 384 aa
MW = 43 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-38}
MOTIF: N-glycosylation site {N20}
transmembrane domain {39-62}
cytoplasmic loop {63-76}
transmembrane domain {77-96}
exoplasmic loop {97-114}
MOTIF: cysteine residue {C113}
MODIFICATION: cysteine residue {C196}
transmembrane domain {115-136}
cytoplasmic loop {137-152}
transmembrane domain {153-174}
exoplasmic loop {175-208}
MOTIF: cysteine residue {C196}
MODIFICATION: cysteine residue {C113}
transmembrane domain {209-234}
cytoplasmic loop {235-264}
transmembrane domain {265-285}
exoplasmic loop {286-298}
transmembrane domain {299-325}
cytoplasmic domain {326-384}
MOTIF: cysteine residue {C339}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM 305670
UniProt P30550
Pfam PF00001
Kegg hsa:2925
References
UniProt :accession P30550