Contents

Search

growth arrest-specific protein 6; GAS-6; AXL receptor tyrosine kinase ligand (GAS6, AXLLG)

Function: - ligand for tyrosine-protein kinase receptors AXL, TYRO3 & MER - implicated in cell growth & survival, cell-cell adhesion & cell migration - role in thrombosis by amplifying platelet aggregation & secretion - role in endothelial cell survival during acidification by preventing apoptosis - role in optimal cytokine signaling during human natural killer cell development - role in hepatic regeneration - role in gonadotropin-releasing hormone neuron survival & migration - isoform 1 is proteolytically processed after secretion to yield a N-terminal 36 kD protein & a C-terminal 50 kD protein including the laminin G-like domains which activates AXL - gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation - these residues are essential for binding of Ca+2 (putative) - heterodimer & heterotetramer with AXL Structure: - contains 4 EGF-like domains - contains 1 Gla (gamma-carboxy-glutamate) domain - contains 2 laminin G-like domains - Gas6 has significant homology with protein S Compartment: secreted Alternative splicing: named isoforms=3 Expression: - plasma - isoform 1 & isoform 2 are widely expressed - isoform 1 is the predominant form in spleen

Related

growth arrest specific gene 6

General

secreted protein

Properties

SIZE: entity length = 721 aa MW = 80 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-30} Gla {53-94} MOTIF: cysteine residue {C65} MODIFICATION: cysteine residue {C70} cysteine residue {C70} MODIFICATION: cysteine residue {C65} EGF domain {116-154} MOTIF: cysteine residue {C120} MODIFICATION: cysteine residue {C133} cysteine residue {C125} MODIFICATION: cysteine residue {C142} cysteine residue {C133} MODIFICATION: cysteine residue {C120} cysteine residue {C142} MODIFICATION: cysteine residue {C125} cysteine residue {C144} MODIFICATION: cysteine residue {C153} cysteine residue {C153} MODIFICATION: cysteine residue {C144} EGF domain {156-196} MOTIF: cysteine residue {C160} MODIFICATION: cysteine residue {C171} cysteine residue {C167} MODIFICATION: cysteine residue {C180} cysteine residue {C171} MODIFICATION: cysteine residue {C160} cysteine residue {C180} MODIFICATION: cysteine residue {C167} cysteine residue {C182} MODIFICATION: cysteine residue {C195} cysteine residue {C195} MODIFICATION: cysteine residue {C182} EGF domain {197-237} MOTIF: cysteine residue {C201} MODIFICATION: cysteine residue {C212} cysteine residue {C207} MODIFICATION: cysteine residue {C221} cysteine residue {C212} MODIFICATION: cysteine residue {C201} cysteine residue {C221} MODIFICATION: cysteine residue {C207} cysteine residue {C223} MODIFICATION: cysteine residue {C236} cysteine residue {C236} MODIFICATION: cysteine residue {C223} EGF domain {238-278} MOTIF: cysteine residue {C242} MODIFICATION: cysteine residue {C251} cysteine residue {C247} MODIFICATION: cysteine residue {C260} cysteine residue {C251} MODIFICATION: cysteine residue {C242} cysteine residue {C260} MODIFICATION: cysteine residue {C247} cysteine residue {C262} MODIFICATION: cysteine residue {C277} cysteine residue {C277} MODIFICATION: cysteine residue {C262} cysteine residue {C326} MODIFICATION: cysteine residue {C613} Laminin G-like 1 {341-513} MOTIF: Ca+2-binding site SITE: 372-372 Ca+2-binding site SITE: 374-374 N-glycosylation site {N463} Ca+2-binding site SITE: 483-483 cysteine residue {C487} MODIFICATION: cysteine residue {C513} cysteine residue {C513} MODIFICATION: cysteine residue {C487} Laminin G-like 2 {520-713} MOTIF: cysteine residue {C613} MODIFICATION: cysteine residue {C326} cysteine residue {C686} MODIFICATION: cysteine residue {C713} Ca+2-binding site SITE: 699-699 cysteine residue {C713} MODIFICATION: cysteine residue {C686}

Database Correlations

OMIM 600441 UniProt Q14393 PFAM correlations Entrez Gene 2621 Kegg hsa:2621

References

  1. Varnum BC et al Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6. Nature 373:623 1995 PMID: 7854420
  2. UniProt :accession Q14393
  3. SeattleSNPs http://pga.gs.washington.edu/data/gas6/