Search
ganglioglioma; dysembryonic neuroepithelial neoplasm
Lumped with dysembryonic neuroepithelial neoplasm
- prognosis & treatment the same [2]
Epidemiology:
- < 30 years of age [2]
Pathology:
- mixed tumor of neuronal & glial derived cells
- may occur anywhere CNS (brain or spinal cord)
- majority occur in temporal lobe
Genetics:
- rare TSC2 gene polymorphism at 3' splice site of intron 4 appears with higher frequency in sporadic gangliogliomas
Clinical manifestations:
- medication-resistant tumors (90%)
Radiology:
- magnetic resonance imaging
- temporal lobe homogeneous or nodular contrast enhancement [2]
Complications:
- anticonvulsant-resistant seizures (90%)
Management:
- neurosurgery: surgical resection
- prognosis:
- rarely limits life expectancy if completely resected [2]
General
brain neoplasm (intracranial neoplasm)
ganglion cell neoplasm
glial neoplasm (glioma)
References
- Platten et al. J Neuropathol Exp Neurol 56:806-10, 1997
- Medical Knowledge Self Assessment Program (MKSAP) 17, 18, 19.
American College of Physicians, Philadelphia 2015, 2018, 2021.
- WHO classification of Tumors of the Central Nervous System.
4th edition.
IARC 2007.
Images
images related to ganglioglioma