gamma-parvin (PARVG)

Function: 1) role in regulation of cell adhesion & cytoskeleton organization (putative) 2) interacts with integrin-linked protein kinase & actin Structure: - belongs to the parvin family - contains 2 CH domains (calponin-homology domains) Compartment: - cell junction, focal adhesion, cytoplasmic side - constituent of focal adhesions Alternative splicing: named isoforms=3 Expression: - expressed in lymphoid organs, including spleen, thymus, lymph node, bone marrow & peripheral blood leukocytes > digestive tract, including stomach, duodenum, jejunum, ileum, ileocecum & appendix = lung, liver Pathology: - expressed in tumors, but at a lower level than in the corresponding normal tissues

Properties

SIZE: MW = 37 kD entity length = 331 aa COMPARTMENT: cytoplasm MOTIF: calponin homology domain NAME: calponin homology domain SITE: 44-151 calponin homology domain NAME: calponin homology domain SITE: 210-317

Database Correlations

OMIM 608122 UniProt Q9HBI0 Pfam PF00307

References

UniProt :accession Q9HBI0