Search
gamma-interferon-inducible lysosomal thiol reductase; gamma-interferon-inducible protein IP-30 (IFI30 GILT)
Function:
- cleaves disulfide bonds in proteins by reduction
- may facilitate the complete unfolding of proteins destined for lysosomal degradation
- may be involved in MHC class II-restrictedantigen processing
Structure:
- N-glycosylated
- sugar chains contain mannose-6-phosphate
- belongs to the GILT family
Compartment: lysosome
Expression:
- expressed constitutively in antigen-presenting cells
- induced by IFN-gamma in other cell types
General
glycoprotein
oxidoreductase
phosphoprotein
Properties
SIZE: entity length = 261 aa
MW = 29 kD
COMPARTMENT: lysosome
MOTIF: signal sequence {1-37}
Thr phosphorylation site {T56}
N-glycosylation site {N74}
cysteine residue {C83}
MODIFICATION: cysteine residue {C86}
cysteine residue {C86}
MODIFICATION: cysteine residue {C83}
N-glycosylation site {N106}
N-glycosylation site {N119}
Database Correlations
OMIM 604664
UniProt P13284
Pfam PF03227
References
UniProt :accession P13284