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gamma-glutamyl hydrolase; conjugase; GH; gamma-Glu-X carboxypeptidase (GGH)
Function:
- hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates
- progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) & free glutamate
- may play an important role in the bioavailability of dietary pteroylpolyglutamates & in the metabolism of pteroylpolyglutamates & antifolates
- hydrolysis of a gamma-glutamyl bond
- homodimer (probable)
Structure:
- belongs to the peptidase C26 family
- contains 1 gamma-glutamyl hydrolase domain
Compartment:
- secreted, extracellular space
- lysosome, melanosome
- intracellular location is primarily the lysosome; however, most of enzyme activity is secreted
- identified by mass spectrometry in melanosome fractions from stage 1 to stage 4
General
carboxypeptidase
glycoprotein
Properties
SIZE: entity length = 318 aa
MW = 36 kD
COMPARTMENT: lysosome
MOTIF: signal sequence {1-24}
Gamma-glutamyl hydrolase {25-318}
MOTIF: N-glycosylation site {N116}
cysteine residue {C134}
N-glycosylation site {N163}
N-glycosylation site {N203}
histidine residue {H244}
N-glycosylation site {N307}
Database Correlations
OMIM 601509
UniProt Q92820
Pfam PF07722
Entrez Gene 8836
Kegg hsa:8836
ENZYME 3.4.19.9
References
- UniProt :accession Q92820
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/GGHID44358ch8q12.html