gamma-glutamyltransferase 7; GGT 7;gamma-glutamyltransferase-like 3; gamma-glutamyltransferase-like 5; gamma-glutamyltranspeptidase 7; contains: gamma-glutamyltransferase 7 heavy chain; gamma-glutamyltransferase 7 light chain (GGT7, GGTL3, GGTL5)

Function: 1) glutathione metabolism 2) cleaves glutathione conjugates 3) Isoform 5 interacts with CT120 Structure: - heterodimer composed of the light & heavy chains, both derived from same precursor - active site located in the light chain Compartment: membrane Alternative splicing: named isoforms=6 Expression: - expressed in brain, heart, kidney, liver, lung, spleen, testis, trachea

General

gamma-glutamyltransferase (GGT) or gamma-glutamyltranspeptidase glycoprotein membrane protein phosphoprotein

Properties

SIZE: entity length = 662 aa MW = 70 kD COMPARTMENT: cellular membrane MOTIF: Ser phosphorylation site {S72} Ser phosphorylation site {S83} transmembrane domain {107-127} N-glycosylation site {N198} N-glycosylation site {N267} N-glycosylation site {N283} N-glycosylation site {N330} N-glycosylation site {N353} N-glycosylation site {N394} N-glycosylation site {N452} N-glycosylation site {N519} N-glycosylation site {N523} N-glycosylation site {N586}

Database Correlations

OMIM 612342 UniProt Q9UJ14 Pfam PF01019 Entrez Gene 2686 Kegg hsa:2686 ENZYME 2.3.2.2

References

UniProt :accession Q9UJ14