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gamma-aminobutyric acid receptor-associated protein-like 2; GABA(A) receptor-associated protein-like 2; ganglioside expression factor 2; GEF-2; general protein transport factor p16; Golgi-associated ATPase enhancer of 16 kD; GATE-16; MAP1 light chain 3-related protein (GABARAPL2, FLC3A, GEF2)
Function:
- intra-Golgi traffic
- modulates intra-Golgi transport via coupling between NSF & SNAREs
- stimulates ATPase activity of NSF which in turn stimulates association with GOSR1
- phosphorylated upon DNA damage, probably by ATM or ATR
- interacts with GABRG2, NSF, GOSR1, beta-tubulin, ULK1
- interacts with TP53INP1 & TP53INP2
- interacts with TBC1D25
Structure:
- monomer
- belongs to the MAP1 LC3 family
Compartment:
- Golgi
- cytoplasmic vesicle, autophagosome
Expression:
- ubiquitous
- expressed at high levels in the brain, heart, prostate, ovary, spleen, skeletal muscle
- expressed at very low levels in lung, thymus, small intestine
Related
GABA-A receptor
gamma-aminobutyric acid receptor-associated protein; GABA(A) receptor-associated protein; MM46 (GABARAP, FLC3B, HT004)
General
cytoskeletal protein
Properties
SIZE: MW = 14 kD
entity length = 117 aa
COMPARTMENT: cytoplasm
golgi
MOTIF: binding site
SITE: 1-22
FOR-BINDING-OF: beta tubulin
MOTIF: Ser phosphorylation site {S10}
binding site
SITE: 36-68
FOR-BINDING-OF: gamma-aminobutyric acid receptor subunit gamma-2
MOTIF: Ser phosphorylation site {S39}
Database Correlations
OMIM 607452
UniProt P60520
Pfam PF02991
Entrez Gene 11345
Kegg hsa:11345
References
UniProt :accession P60520