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gamma-aminobutyric acid receptor-associated protein-like 1; early estrogen-regulated protein; GABA(A) receptor-associated protein-like 1; glandular epithelial cell protein 1; GEC-1 (GABARAPL1, GEC1)
Function:
- increases cell-surface expression of opioid kappa receptor through facilitating anterograde intracellular trafficking of the receptor
- interacts with GABRG2 & beta-tubulin (putative)
- interacts with OPRK1
- interacts with TP53INP1 & TP53INP2
Structure: belongs to the MAP1 LC3 family
Compartment:
- cytoplasm, cytoskeleton
- endoplasmic reticulum, Golgi (putative)
- cytoplasmic vesicle, autophagosome
Expression:
- ubiquitous
- expressed at very high levels brain, heart, peripheral blood leukocytes, liver, kidney, placenta & skeletal muscle
- expressed at very low levels in thymus, small intestine
Related
GABA-A receptor
gamma-aminobutyric acid receptor-associated protein; GABA(A) receptor-associated protein; MM46 (GABARAP, FLC3B, HT004)
General
cytoskeletal protein
Properties
SIZE: MW = 14 kD
entity length = 117 aa
COMPARTMENT: cytoplasm
golgi
endoplasmic reticulum
MOTIF: binding site
SITE: 1-22
FOR-BINDING-OF: beta tubulin
binding site
SITE: 36-68
FOR-BINDING-OF: gamma-aminobutyric acid receptor subunit gamma-2
Database Correlations
OMIM 607420
UniProt Q9H0R8
Pfam PF02991
Entrez Gene 23710
Kegg hsa:23710
References
UniProt :accession Q9H0R8