gamma-aminobutyric acid receptor-associated protein; GABA(A) receptor-associated protein; MM46 (GABARAP, FLC3B, HT004)

Function: - intracellular transport of GABA-A receptors - interaction with the cytoskeleton - role in apoptosis - interacts with GPHN, NSF, GABRG2, beta-tubulin, ULK1 - interacts with CALR - interacts with DDX47 - interacts with TP53INP1 & TP53INP2 - interacts with TBC1D25 Structure: belongs to the MAP1 LC3 family Compartment: - cytoplasm, cytoskeleton - endomembrane system, Golgi, post-synaptic cisternae - cytoplasmic vesicle, autophagosome - colocalizes with microtubules Expression: - expressed in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas

Related

GABA-A receptor gamma-aminobutyric acid receptor-associated protein-like 1; early estrogen-regulated protein; GABA(A) receptor-associated protein-like 1; glandular epithelial cell protein 1; GEC-1 (GABARAPL1, GEC1)

Properties

SIZE: MW = 14 kD entity length = 117 aa COMPARTMENT: golgi MOTIF: binding site SITE: 1-22 FOR-BINDING-OF: beta tubulin binding site SITE: 36-117 FOR-BINDING-OF: gephyrin MOTIF: binding site SITE: 36-68 FOR-BINDING-OF: gamma-aminobutyric acid receptor subunit gamma-2

Database Correlations

OMIM 605125 UniProt O95166 Pfam PF02991 Entrez Gene 11337 Kegg hsa:11337

References

UniProt :accession O95166