Search
galectin-3-binding protein (lectin galactoside-binding soluble 3-binding protein, Mac-2-binding protein, Mac-2 BP, MAC2BP, tumor-associated antigen 90K, LGALS3BP, M2BP)
Function:
1) promotes integrin-mediated cell adhesion
2) may stimulate host defense against viruses & tumor cells
3) binds LGALS1, LGALS3, ITGB1, COL4A1, COL5A1, COL6A1, FN1, NID
Structure:
- homodimers & homomultimers
- multimers form ring-like structures with a diameter of 30-40 nm
Compartment: secreted
Expression:
- ubiquitous
- detected in body fluids, i.e. semen, milk, serum, tears, saliva & urine
Related
galectin-3; galactose-specific lectin 3; mac-2 antigen; IgE-binding protein; 35 kD lectin; carbohydrate-binding protein 35; CBP 35; laminin-binding protein; lectin L-29; L-31; galactoside-binding protein; GALBP (LGALS3 MAC2)
General
glycoprotein
secreted protein
Properties
SIZE: MW = 65 kD
entity length = 585 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-18}
SRCR {24-124}
MOTIF: cysteine residue {C49}
MODIFICATION: cysteine residue {C113}
cysteine residue {C62}
MODIFICATION: cysteine residue {C123}
N-glycosylation site {N69}
cysteine residue {C93}
MODIFICATION: cysteine residue {C103}
cysteine residue {C103}
MODIFICATION: cysteine residue {C93}
cysteine residue {C113}
MODIFICATION: cysteine residue {C49}
cysteine residue {C123}
MODIFICATION: cysteine residue {C62}
N-glycosylation site {N125}
BTB domain {153-221}
MOTIF: Zinc finger
NAME: Zinc finger
EFFECTOR-BOUND: Zn+2
N-glycosylation site {N192}
N-glycosylation site {N362}
N-glycosylation site {N398}
N-glycosylation site {N551}
N-glycosylation site {N580}
Database Correlations
OMIM 600626
UniProt Q08380
PFAM correlations
References
UniProt :accession Q08380