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galanin receptor type 2; GAL2-R; GALR2 (GALR2, GALNR2)
Function:
- receptor for the hormone galanin & for GALP
- activity is mediated by Gq proteins & Gi proteins
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- expressed abundantly within the central nervous system in both hypothalamus & hippocampus.
- in peripheral tissues, expression is strongest in heart, kidney, liver, & small intestine
Related
galanin; galanin peptide; GMAP (GAL, GAL1, GALN GLNN)
General
galanin receptor
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 387 aa
MW = 42 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-28}
MOTIF: N-glycosylation site {N2}
N-glycosylation site {N11}
transmembrane domain {29-49}
cytoplasmic loop {50-60}
transmembrane domain {61-81}
exoplasmic loop {82-99}
MOTIF: cysteine residue {C98}
MODIFICATION: cysteine residue {C175}
transmembrane domain {100-121}
cytoplasmic loop {122-141}
transmembrane domain {142-162}
exoplasmic loop {163-187}
MOTIF: cysteine residue {C175}
MODIFICATION: cysteine residue {C98}
transmembrane domain {188-208}
cytoplasmic loop {209-237}
MOTIF: Tyr phosphorylation site {Y213}
transmembrane domain {238-258}
exoplasmic loop {259-260}
transmembrane domain {261-281}
cytoplasmic domain {282-387}
Database Correlations
OMIM 603691
UniProt O43603
Pfam PF00001
Entrez Gene 8811
Kegg hsa:8811
References
UniProt :accession O43603