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galactose-3-O-sulfotransferase 4; gal3ST-4; beta-galactose-3-O-sulfotransferase 4; gal-beta-1,3-galNAc 3'-sulfotransferase (GAL3ST4)
Function:
- catalyzes transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins
- good substrates include asialofetuin, gal-beta-1,3-galNAc & gal-beta-1,3 (GlcNAc-beta-1,6)galNAc
- protein modification; carbohydrate sulfation
Cofactor: Mn+2
Kinetic parameters:
- pH dependence: optimum pH is 6-7
Structure:
- belongs to the galactose-3-O-sulfotransferase family
Compartment:
- Golgi, Golgi stack membrane
- single-pass type 2 membrane protein (probable)
Expression:
- expressed mainly in placenta, thymus, testis, ovary, spinal cord, trachea & adrenal gland
- expressed at low levels in brain, lung, spleen, prostate, small intestine, colon, stomach thyroid & lymph node
General
glycoprotein
membrane protein
sulfotransferase
Properties
SIZE: entity length = 486 aa
MW = 54 kD
COMPARTMENT: golgi
MOTIF: transmembrane domain {19-39}
N-glycosylation site {N374}
Database Correlations
OMIM 608235
UniProt Q96RP7
Pfam PF06990
Entrez Gene 79690
Kegg hsa:79690
References
- UniProt :accession Q96RP7
- GGDB; Note: glycogene database
http://riodb.ibase.aist.go.jp/rcmg/ggdb/