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galactose-3-O-sulfotransferase 3; gal3ST-3; beta-galactose-3-O-sulfotransferase 3; gal3ST3; gal-beta-1, 3-galNAc 3'-sulfotransferase 3 (GAL3ST3)
Function:
- transfers a sulfate to position 3 of non-reducing beta-galactosyl residues in N-glycans & core2-branched O-glycans
- high activity towards gal-beta-1,4-GlcNAc, gal-beta-1,4(fuc-alpha-1,3)GlcNAc
- lower activity towards gal-beta-1,3(fuc-alpha-1,4)GlcNAc
- protein modification; carbohydrate sulfation
Cofactor: Mg+2
Kinetic parameters:
- pH dependence: optimum pH is 7.0-8.0
Structure: belongs to the galactose-3-O-sulfotransferase family
Compartment:
- Golgi, Golgi stack membrane
- single-pass type 2 membrane protein (probable)
Expression:
- highly expressed in thyroid, brain, kidney, heart & spinal cord
General
glycoprotein
membrane protein
sulfotransferase
Properties
SIZE: entity length = 431 aa
MW = 49 kD
COMPARTMENT: golgi
MOTIF: transmembrane domain {20-40}
N-glycosylation site {N91}
N-glycosylation site {N110}
N-glycosylation site {N177}
N-glycosylation site {N302}
Database Correlations
OMIM 608234
UniProt Q96A11
Pfam PF06990
Entrez Gene 89792
Kegg hsa:89792
References
- UniProt :accession Q96A11
- GGDB; Note: glycogene database
http://riodb.ibase.aist.go.jp/rcmg/ggdb/