Search
galactose-3-O-sulfotransferase 2; gal3ST-2; beta-galactose-3-O-sulfotransferase 2; gal-beta-1, 3-galNAc 3'-sulfotransferase 2; glycoprotein beta-gal 3'-sulfotransferase 2 (GAL3ST2, GP3ST)
Function:
- transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues
- acts both on type 1 (gal-beta-1,3-GlcNAc) & type 2 (gal-beta-1,4-GlcNAc) chains with similar efficiency
- protein modification; carbohydrate sulfation
Kintetic parameters:
- pH dependence: optimum pH is 6.0-6.5
Inhibition:
- strongly inhibited by Cu+2 & Zn+2
Structure: belongs to the galactose-3-O-sulfotransferase family
Compartment:
- Golgi, Golgi stack membrane
- single-pass type 2 membrane protein (probable)
Expression:
- ubiquitous
- detected in heart, stomach, colon, liver & spleen, placenta, renal tubules, & neurons of the cerebral cortex
General
glycoprotein
membrane protein
sulfotransferase
Properties
SIZE: entity length = 398 aa
MW = 46 kD
COMPARTMENT: golgi
MOTIF: transmembrane domain {11-31}
N-glycosylation site {N79}
N-glycosylation site {N132}
N-glycosylation site {N179}
arginine-rich region {211-315}
MOTIF: arginine residue (SEVERAL)
N-glycosylation site {N287}
N-glycosylation site {N330}
N-glycosylation site {N360}
Database Correlations
OMIM 608237
UniProt Q9H3Q3
Pfam PF06990
Entrez Gene 64090
Kegg hsa:64090
ENZYME 2.8.2._
References
- UniProt :accession Q9H3Q3
- GGDB; Note: glycogene database
http://riodb.ibase.aist.go.jp/rcmg/ggdb/