growth arrest & DNA-damage inducible-45 (GADD45)

The 45 presumably reflects apparent molecular weight. Binding of GADD45 to PCNA may displace PCNA from Cdk complexes.

Related

growth arrest & DNA-damage-inducible proteins-interacting protein 1 (CR6-interacting factor 1, CRIF1, CK2 beta-associating protein, papillomavirus L2-interacting nuclear protein 1, PLINP-1, GADD45GIP1, PLINP1) Growth-arrest & DNA damage-inducible 45 [GADD45] gene

Specific

growth arrest & DNA-damage-inducible protein GADD45 alpha; GAD45-alpha; DNA-damage-inducible transcript 1; DDIT-1 (GADD45A, DDIT1, GADD45) growth arrest & DNA-damage-inducible protein GADD45 beta; myeloid differentiation primary response protein MyD118; negative growth regulatory protein MyD118 (GADD45B, MYD118) growth arrest & DNA-damage-inducible protein GADD45 gamma; cytokine-responsive protein CR6; DNA-damage-inducible transcript 2; DDIT-2 (GADD45G CR6 DDIT2)

Properties

COMPARTMENT: cell nucleus MOTIF: binding site FOR-BINDING-OF: proliferating cell nuclear antigen

References

- Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science. 1994 Nov 25;266(5189):1376-80. PMID: 7973727