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gamma-aminobutyric acid (GABA) B receptor

gamma amino butyric acid [GABA]-B receptor. Pathology: - autoantibody associated with paraneoplastic limbic encephalitis due to small cell lung cancer or thymoma [3] Laboratory: - GABBR Ab in serum - GABBR IgG in serum - GABBR IgG in CSF

Related

anti-GABA B receptor

Specific

gamma-aminobutyric acid (GABA) B receptor, 1 (GABBR1, GPRC3A) gamma-aminobutyric acid type B receptor subunit 2; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABABR2; Gb2; G-protein coupled receptor 51; HG20 (GABBR2, GPR51, GPRC3B)

General

gamma amino butyric acid [GABA] receptor G-protein coupled receptor; serpentine receptor

Properties

COMPARTMENT: synaptic membrane CELL: neuron MOTIF: exoplasmic domain {N-TERMINAL} transmembrane domain {TM1} transmembrane domain {TM2} transmembrane domain {TM3} transmembrane domain {TM4} transmembrane domain {TM5} transmembrane domain {TM6} transmembrane domain {TM7} binding site SITE: C-TERMINAL-CYS EFFECTOR-BOUND: palmitate BOUND-VIA: carboxylate cytoplasmic domain {C-TERMINAL} MISC-INFO: LIGAND = GABA INHIBITOR = PHACLOFEN

References

  1. VanDongen AM, Codina J, Olate J, Mattera R, Joho R, Birnbaumer L, Brown AM. Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go. Science. 1988 Dec 9;242(4884):1433-7. PMID: 3144040
  2. Baumann PA, Wicki P, Stierlin C, Waldmeier PC. Investigations on GABAB receptor-mediated autoinhibition of GABA release. Naunyn Schmiedebergs Arch Pharmacol. 1990 Jan-Feb;341(1-2):88-93. PMID: 2156176
  3. Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015