gamma-aminobutyric acid receptor subunit pi; GABA(A) receptor subunit pi (GABRP)

Function: - GABA-A receptor subunit - in the uterus, the function of the receptor appears to be related to tissue contractility - binding of GABRP with other GABA-A receptor subunits alters sensitivity of recombinant receptors to modulatory agents such as pregnanolone - may bind homomeric GABA-A receptor rho complexes Structure: - belongs to the ligand-gated ionic channel (TC 1.A.9) family Compartment: - cell junction, synapse, postsynaptic cell membrane Expression: - most abundant in the uterus - also expressed in lung, thymus & prostate

General

glycoprotein ionotropic receptor subunit transmembrane 4e protein

Properties

SIZE: entity length = 440 aa MW = 51 kD COMPARTMENT: plasma membrane MOTIF: exoplasmic domain {1-242} MOTIF: signal sequence {1-16} N-glycosylation site {N43} N-glycosylation site {N102} N-glycosylation site {N145} cysteine residue {C160} MODIFICATION: cysteine residue {C174} cysteine residue {C174} MODIFICATION: cysteine residue {C160} N-glycosylation site {N196} N-glycosylation site {N228} transmembrane domain {243-266} cytoplasmic loop {267-269} transmembrane domain {270-292} exoplasmic loop {293-304} transmembrane domain {305-327} cytoplasmic loop {328-416} transmembrane domain {417-438} exoplasmic domain {439-440}

Database Correlations

OMIM 602729 UniProt O00591 PFAM correlations Entrez Gene 2568 Kegg hsa:2568

References

UniProt :accession O00591