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trafficking kinesin-binding protein 2; GABA-A receptor-interacting factor 1; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein (TRAK2, ALS2CR3, GRIF1, KIAA0549)
Function:
- may regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR
- interacts with GABA-A receptor & O-GlcNAc transferase
- interacts with HGS (putative)
- interacts with RHOT1/Miro-1 & RHOT2/Miro-2
Structure:
- O-glycosylated (putative)
- contains 1 HAP1 N-terminal domain
Compartment:
- cytoplasm (putative), early endosome
Expression:
- widely expressed
- highest expression in heart
Related
amyotrophic lateral sclerosis (ALS); Lou Gerig's disease
amyotrophic lateral sclerosis [ALS] 2 chromosomal region candidate gene
General
cytoskeletal protein
Properties
SIZE: entity length = 914 aa
MW = 101 kD
COMPARTMENT: cytoplasm
MOTIF: coiled coil {134-354}
HGS interaction {359-509}
Database Correlations
OMIM 607334
UniProt O60296
PFAM correlations
Entrez Gene 66008
Kegg hsa:66008
References
UniProt :accession O60296