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gamma-aminobutyric acid receptor subunit gamma-3; GABA(A) receptor subunit gamma-3 (GABRG3)
Function:
- GABA-A receptor gamma subunit
- this subunit carries the benzodiazepine binding site
- may be palmitoylated
Structure:
- belongs to the ligand-gated ionic channel (TC 1.A.9) family
Compartment:
- cell junction, synapse, postsynaptic cell membrane
General
gamma-aminobutyric acid (GABA) A receptor, gamma
glycoprotein
transmembrane 4e protein
Properties
SIZE: entity length = 467 aa
MW = 54 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-254}
MOTIF: signal sequence {1-17}
N-glycosylation site {N110}
cysteine residue {C171}
MODIFICATION: cysteine residue {C185}
cysteine residue {C185}
MODIFICATION: cysteine residue {C171}
N-glycosylation site {N228}
transmembrane domain {255-277}
cytoplasmic loop {278-280}
transmembrane domain {281-303}
exoplasmic loop {304-314}
transmembrane domain {315-337}
cytoplasmic loop {338-443}
transmembrane domain {444-467}
exoplasmic domain {467-467}
Database Correlations
OMIM 600233
UniProt Q99928
PFAM correlations
Entrez Gene 2567
Kegg hsa:2567
References
- UniProt :accession Q99928
- Protein Spotlight; Note: forbidden fruit -
Issue 56 of march 2005
http://www.expasy.org/spotlight/back_issues/sptlt056.shtml