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gamma-aminobutyric acid receptor subunit alpha-4; GABA(A) receptor subunit alpha-4 (GABRA4)
Function:
- GABA-A receptor alpha subunit
Structure:
- belongs to the ligand-gated ionic channel (TC 1.A.9) family
Compartment:
- cell junction, synapse, postsynaptic cell membrane
Expression:
- the alpha4 beta2 gamma 2L receptor is not repressed by diazepam
General
gamma-aminobutyric acid (GABA) A receptor, alpha
glycoprotein
transmembrane 4e protein
Properties
SIZE: entity length = 554 aa
MW = 62 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-258}
MOTIF: signal sequence {1-35}
N-glycosylation site {N47}
Ser phosphorylation site {S140}
Ser phosphorylation site {S142}
N-glycosylation site {N144}
N-glycosylation site {N157}
cysteine residue {C172}
MODIFICATION: cysteine residue {C186}
cysteine residue {C186}
MODIFICATION: cysteine residue {C172}
transmembrane domain {259-280}
cytoplasmic loop {281-284}
transmembrane domain {285-306}
exoplasmic loop {307-317}
transmembrane domain {318-340}
cytoplasmic loop {341-523}
transmembrane domain {524-543}
exoplasmic domain {544-554}
Database Correlations
OMIM 137141
UniProt P48169
PFAM correlations
Entrez Gene 2557
Kegg hsa:2557
References
- UniProt :accession P48169
- Protein Spotlight; Note: forbidden fruit -
Issue 56 of March 2005
http://www.expasy.org/spotlight/back_issues/sptlt056.shtml