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epithelial cell adhesion molecule; Ep-CAM; tumor-associated Ca+2 signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; epithelial cell surface antigen; epithelial glycoprotein; EGP; epithelial glycoprotein 314; EGP314; hEGP314; adenocarcinoma-associated antigen; KSA; KS 1/4 antigen; cell surface glycoprotein trop-1; CD326 (EPCAM, GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1)
Function:
- may act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) & intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection
Structure:
- monomer
- belongs to the EPCAM family
- contains 1 thyroglobulin type-1 domain
Compartment:
- membrane; single-pass type 1 membrane protein
Expression:
- expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes
- found on the surface of adenocarcinomas
Laboratory:
- circulating tumor cell count identifies & quantifies EpCAM produced by epithelial tumor cells (carcinomas) [3]
Pharmacology:
- target of sacituzumab govitecan-hziy (Trodelvy), a drug FDA-approved for refractory triple-negative breast cancer
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
tumor (cancer or CA) antigen
Properties
SIZE: entity length = 314 aa
MW = 35 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-23}
cysteine residue {C27}
MODIFICATION: cysteine residue {C46}
cysteine residue {C29}
MODIFICATION: cysteine residue {C59}
cysteine residue {C38}
MODIFICATION: cysteine residue {C48}
cysteine residue {C46}
MODIFICATION: cysteine residue {C27}
cysteine residue {C48}
MODIFICATION: cysteine residue {C38}
cysteine residue {C59}
MODIFICATION: cysteine residue {C29}
Thyroglobulin type-1 {63-135}
MOTIF: cysteine residue {C66}
MODIFICATION: cysteine residue {C99}
N-glycosylation site {N74}
cysteine residue {C99}
MODIFICATION: cysteine residue {C66}
cysteine residue {C110}
MODIFICATION: cysteine residue {C116}
N-glycosylation site {N111}
cysteine residue {C116}
MODIFICATION: cysteine residue {C110}
cysteine residue {C118}
MODIFICATION: cysteine residue {C135}
cysteine residue {C135}
MODIFICATION: cysteine residue {C118}
N-glycosylation site {N198}
transmembrane domain {266-288}
Database Correlations
OMIM 185535
UniProt P16422
Pfam PF00086
Entrez Gene 4072
References
- UniProt :accession P16422
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/TACSTD1ID42459ch2p21.html
- ARUP Consult: Circulating Tumor Cell Count
https://arupconsult.com/ati/circulating-tumor-cell-count