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tumor-associated Ca+2 signal transducer 2; pancreatic carcinoma marker protein GA733-1; cell surface glycoprotein trop-2 (TACSTD2, GA733-1, M1S1, TROP2)
Function:
- may function as a growth factor receptor
- the N-terminus is blocked
Structure:
- belongs to the EPCAM family
- contains 1 thyroglobulin type-1 domain
Compartment:
- membrane; single-pass type 1 membrane protein
Expression: placenta, pancreatic carcinoma cell lines
Pathology:
- defects in TACSTD2 are the cause of gelatinous drop-like corneal dystrophy
General
glycoprotein
membrane protein
phosphoprotein
tumor (cancer or CA) antigen
Properties
SIZE: entity length = 323 aa
MW = 36 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-26}
N-glycosylation site {N33}
Thyroglobulin type-1 {70-145}
MOTIF: cysteine residue {C73}
MODIFICATION: cysteine residue {C108}
cysteine residue {C108}
MODIFICATION: cysteine residue {C73}
cysteine residue {C119}
MODIFICATION: cysteine residue {C125}
N-glycosylation site {N120}
cysteine residue {C125}
MODIFICATION: cysteine residue {C119}
cysteine residue {C127}
MODIFICATION: cysteine residue {C145}
cysteine residue {C145}
MODIFICATION: cysteine residue {C127}
N-glycosylation site {N168}
N-glycosylation site {N208}
transmembrane domain {275-297}
Ser phosphorylation site {S322}
Database Correlations
OMIM correlations
UniProt P09758
Pfam PF00086
Entrez Gene 4070
Kegg hsa:4070
References
- UniProt :accession P09758
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=TACSTD2