G6b protein (G6B, C6orf25)

Function: 1) isoform B is a putative inhibitory receptor 2) isoform A may be its activating counterpart 3) interacts with PTPN6 & PTPN11 Structure: - all isoforms are N-glycosylated - isoform E is O-glycosylated - isoform A: cell membrane - isoform B: cell membrane - isoform D: endoplasmic reticulum, Golgi - isoform E: endoplasmic reticulum, Golgi - isoforms D & E lack the transmembrane regions, thus remain in the endoplasmic reticulum &/or Golgi Alternative splicing: named isoforms=7 Expression: expressed in a restricted set of hematopoietic cell lines Pathology: - expressed in transformed cell lines - erythroleukemia cell line K562 - T-cell leukemia cell lines Molt4 & Jurkat

General

glycoprotein membrane protein phosphoprotein receptor

Properties

SIZE: MW = 26 kD entity length = 241 aa COMPARTMENT: golgi endoplasmic reticulum MOTIF: signal sequence {1-17} N-glycosylation site {N32} transmembrane domain {143-163} Tyr phosphorylation site {Y211}

Database Correlations

OMIM 606520 UniProt O95866

References

UniProt :accession O95866