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G2 & S phase expressed protein 1 (B99 homolog, GTSE1)
Function:
- role in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements required to enter mitosis
- overexpression delays G2/M phase progression
- phosphorylated in mitosis
Compartment: cytoplasm, associated with microtubules
Expression:
- expressed in G2/M phase
- not detected in quiescent cells
General
microtubule-associated protein (MAP)
phosphoprotein
Properties
SIZE: MW = 77 kD
entity length = 720 aa
COMPARTMENT: cytoplasm
MOTIF: serine-rich region {22-27}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S168}
Ser phosphorylation site {S494}
Ser phosphorylation site {S495}
Ser phosphorylation site {S501}
Ser phosphorylation site {S504}
Ser phosphorylation site {S536}
Ser phosphorylation site {S575}
Ser phosphorylation site {S580}
Ser phosphorylation site {S592}
Database Correlations
OMIM 607477
UniProt Q9NYZ3
References
UniProt :accession Q9NYZ3