Contents

Search

lysine-specific demethylase 2A; JmjC domain-containing histone demethylation protein 1A; [histone-H3]-lysine-36 demethylase 1A; F-box/LRR-repeat protein 11; F-box & leucine-rich repeat protein 11; F-box protein FBL7; F-box protein Lilina; CXXC-type zinc finger protein 8 (KDM2A, CXXC8, FBL7, FBXL11, JHDM1A, KIAA1004)

Function: 1) histone demethylase 2) demethylates Lys-36 of histone H3 - preferentially demethylates dimethylated H3 Lys-36 with weak or no activity for mono- & tri-methylated H3 Lys-36 3) role in histone code 4) recognizes & binds to phosphorylated proteins & promotes their ubiquitination & degradation (putative) 5) required to maintain the heterochromatic state 6) associates with centromeres & represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere 7) required to sustain centromeric integrity & genomic stability, particularly during mitosis 8) component of SKP1-cullin-F-box protein ligase complex (SCF complex) 9) interacts with CBX5/HP1A; the interaction promotes CBX5 localization to chromatin protein N(6),N(6)-dimethyl-L-lysine + 2-oxoglutarate + O2 protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO2 protein N(6)-methyl-L-lysine + 2-oxoglutarate + O2 protein L-lysine + succinate + formaldehyde + CO2 Cofactor: binds 1 Fe+2 ion per subunit Structure: - the JmjC domain mediates demethylation activity & is required for satellite silencing - belongs to the JHDM1 histone demethylase family - contains 1 CXXC-type Zn+2 finger - contains 1 F-box domain - contains 1 JmjC domain - contains 3 LRR repeats (leucine-rich repeats) - contains 1 PHD-type Zn+2 finger Compartment: - nucleus, nucleoplasm - punctate expression throughout the nucleoplasm & enriched in the perinucleolar region Alternative splicing: named isoforms=3 Expression: widely expressed: brain, testis, ovary > lung

General

F-box & leucine-rich repeat protein histone demethylase hydroxylase; monooxygenase phosphoprotein zinc finger protein

Properties

SIZE: entity length = 1162 aa MW = 133 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S28} JmjC {148-316} MOTIF: binding site SITE: 209-209 FOR-BINDING-OF: Substrate Iron [Fe]-binding site SITE: 212-212 Iron [Fe]-binding site SITE: 214-214 binding site SITE: 229-229 FOR-BINDING-OF: Substrate Iron [Fe]-binding site SITE: 284-284 Ser phosphorylation site {S390} Ser phosphorylation site {S394} Thr phosphorylation site {T534} Thr phosphorylation site {T550} Ser phosphorylation site {S558} Zinc finger NAME: Zinc finger SITE: 564-610 EFFECTOR-BOUND: Zn+2 Zn finger PHD-type NAME: Zn finger PHD-type SITE: 617-678 EFFECTOR-BOUND: Zn+2 MOTIF: Thr phosphorylation site {T632} Ser phosphorylation site {S692} Thr phosphorylation site {T713} Ser phosphorylation site {S718} Thr phosphorylation site {T720} Ser phosphorylation site {S721} Ser phosphorylation site {S731} Ser phosphorylation site {S739} Ser phosphorylation site {S740} Ser phosphorylation site {S832} Thr phosphorylation site {T844} Ser phosphorylation site {S869} F-box domain {889-936} leucine-rich repeat SITE: 1000-1025 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 1063-1091 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 1095-1118 MOTIF: leucine residue (SEVERAL)

Database Correlations

OMIM 605657 UniProt Q9Y2K7 PFAM correlations Entrez Gene 22992 Kegg hsa:22992 ENZYME 1.14.11.27

References

  1. OMIM :accession 605657
  2. UniProt :accession Q9Y2K7