Contents

Search

F actin-capping protein, cCAP39, MCP or Cap-Z protein

Function: - F-actin-capping proteins bind to the fast growing ends of actin filaments (barbed end) thus blocking the exchange of subunits at these ends (Ca+2-independent) - unlike other capping proteins (such as gelsolin & severin), these proteins do not sever actin filaments Subunits: - F-actin capping protein alpha subunit - F-actin capping protein beta subunit

Related

F-actin capping protein alpha-1 subunit (CapZ alpha-1, CAPZA1) F-actin-capping protein subunit alpha-2 (CapZ alpha-2, CAPZA2) F-actin-capping protein subunit beta (CapZ beta, CAPZB)

General

Ca+2 binding protein cytoskeletal protein multisubunit protein

Properties

COMPARTMENT: cytoplasm MOTIF: Ca+2-binding site binding site FOR-BINDING-OF: F-actin binding site FOR-BINDING-OF: phosphatidylinositol-4,5-phosphate SUBUNITS: F-actin capping protein alpha subunit F-actin-capping protein subunit beta MOTIF: Ser phosphorylation site {S182}

References

  1. Yu FX, Johnston PA, Sudhof TC, Yin HL. gCap39, a calcium ion- and polyphosphoinositide-regulated actin capping protein. Science. 1990 Dec 7;250(4986):1413-5. PMID: 2255912
  2. Stossel TP. On the crawling of animal cells. Science. 1993 May 21;260(5111):1086-94. Review. PMID: 8493552
  3. Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 896

Components

F-actin capping protein alpha subunit F-actin-capping protein subunit beta (CapZ beta, CAPZB)