Fragile X mental retardation syndrome-related protein 1; hFXR1p (FXR1)

Function: - RNA-binding protein required for embryonic & postnatal development of muscle tissue - may regulate intracellular transport & local translation of certain mRNAs (putative) - interacts with FMR1 & FXR2. interacts with TDRD3, & with CYFIP2 but not with CYFIP1 Structure: - belongs to the FMR1 family - contains 2 KH domains - Arg-445 is dimethylated, probably to asymmetric dimethylarginine Compartment: cytoplasm Alternative splicing: named isoforms=3; alternative splicing appears to be tissue-specific Expression: - expressed in all tissues examined including heart, brain, kidney & testis

General

nuclear protein phosphoprotein RNA-binding protein

Properties

SIZE: entity length = 621 aa MW = 70 kD COMPARTMENT: cytoplasm MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl proline-rich region SITE: 50-53 MOTIF: proline residue (SEVERAL) Tyr phosphorylation site {Y68} KH domain SITE: 222-251 FOR-BINDING-OF: ribonucleic acid KH domain SITE: 285-314 FOR-BINDING-OF: ribonucleic acid Ser phosphorylation site {S406} Ser phosphorylation site {S409} binding site SITE: 442-457 FOR-BINDING-OF: ribonucleic acid Tyr phosphorylation site {Y477} arginine-rich region {502-510} MOTIF: arginine residue (SEVERAL) Ser phosphorylation site {S585}

Database Correlations

OMIM 600819 UniProt P51114 PFAM correlations Entrez Gene 8087 Kegg hsa:8087

References

UniProt :accession P51114