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FXI-ASO
Indications:
- prophylaxis for venous thromboembolism
- prevents DVT after total knee arthroplasty better than enoxaparin [1]
Dosage:
- 200 mg QD
Adverse effects:
- hemorrhage may be less than with enoxaparin
Mechanism of action:
- antisense oligonucleotide
- reduces the level of factor XI
Interactions
drug adverse effects of antithrombotic agent(s)
General
short interfering double-stranded RNA; antisense oligonucleotide (siRNA, microRNA, miRNA)
anticoagulant
References
- Buller HR et al
Factor XI Antisense Oligonucleotide for Prevention of Venous
Thrombosis
N Engl J Med. Dec 7, 2014
PMID: 25482425
http://www.nejm.org/doi/full/10.1056/NEJMoa1405760
- Flaumenhaft R
Making (Anti)Sense of Factor XI in Thrombosis.
N Engl J Med. Dec 7, 2014
PMID: 25482334
http://www.nejm.org/doi/full/10.1056/NEJMe1413874