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fucosyltransferase 9; alpha-(1,3)-fucosyltransferase; fucosyltransferase IX; fuc-TIX; fucT-IX; galactoside 3-L-fucosyltransferase (FUT9)
Function:
1) transfers fucose to lacto-N-neotetraose
- but not to either
- alpha2,3-sialyl lacto-N-neotetraose
- lacto-N-tetraose.
2) can catalyze last step in the biosynthesis of Lewis antigen,
3) addition of a fucose to precursor polysaccharides
4) protein glycosylation.
Structure: belongs to the glycosyltransferase 10 family
Compartment:
- Golgi
- single-pass type 2 membrane protein (putative)
Expression:
- expressed in forebrain, stomach > spleen, peripheral blood leukocytes
- No expression in small intestine, colon, liver, lung, kidney, adrenal cortex, uterus
Related
alpha-(1,3)-fucosyltransferase
General
fucosyltransferase
glycoprotein
membrane protein
Properties
SIZE: entity length = 359 aa
MW = 42 kD
COMPARTMENT: golgi
MOTIF: transmembrane domain {12-32}
N-glycosylation site {N62}
N-glycosylation site {N101}
N-glycosylation site {N153}
Database Correlations
OMIM 606865
UniProt Q9Y231
Pfam PF00852
Entrez Gene 10690
Kegg hsa:10690
References
- UniProt :accession Q9Y231
- GGDB; Note: glycogene database
http://riodb.ibase.aist.go.jp/rcmg/ggdb/homolog?cat=symbol&symbol=FUT9
- Functional glycomics gateway - GTase
Note: fucosyltransferase 9
http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewglycoEnzyme.jsp?gbpId=gt_hum_606