FUBP2/PTBP1/PTBP2/HNRPH1 complex selections

FUBP2/PTBP1/PTBP2/HNRPH1 complex

Function: - binds to the downstream control sequence of pre-mRNA - mediates exon inclusion in transcripts subject to alternative splicing - may interact with single-stranded DNA from the far-upstream element (FUSE) - may activate gene expression Structure: - subunits: FUBP2, PTBP1, PTBP2 & HNRPH1

General

molecular complex nuclear protein

Properties

COMPARTMENT: cell nucleus SUBUNITS: far upstream element-binding protein 2 COMPARTMENT: cytoplasm cell nucleus MOTIF: Thr phosphorylation site {T6} proline-rich region SITE: 7-67 MOTIF: proline residue (SEVERAL) glycine-rich region {68-496} MOTIF: Ser phosphorylation site {S99} Thr phosphorylation site {T100} Ser phosphorylation site {S132} KH domain SITE: 144-208 FOR-BINDING-OF: ribonucleic acid Ser phosphorylation site {S181} Ser phosphorylation site {S184} KH domain SITE: 233-299 FOR-BINDING-OF: ribonucleic acid Ser phosphorylation site {S274} KH domain SITE: 322-386 FOR-BINDING-OF: ribonucleic acid KH domain SITE: 424-491 FOR-BINDING-OF: ribonucleic acid Ser phosphorylation site {S480} proline-rich region SITE: 498-612 MOTIF: proline residue (SEVERAL) 4 X 12 AA imperfect repeats {571-684} MOTIF: consensus repeat {571-582} consensus repeat {617-628} consensus repeat {643-654} Ser phosphorylation site {S670} consensus repeat {673-684} polypyrimidine tract-binding protein 1 COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S16} RNP motif NAME: RNP motif SITE: 59-143 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Tyr phosphorylation site {Y127} Ser phosphorylation site {S141} RNP motif NAME: RNP motif SITE: 184-260 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif alanine-rich region {316-323} MOTIF: alanine residue (SEVERAL) RNP motif NAME: RNP motif SITE: 337-411 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S433} RNP motif NAME: RNP motif SITE: 454-529 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif polypyrimidine tract-binding protein 2 COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S27} RNP motif NAME: RNP motif SITE: 59-133 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif RNP motif NAME: RNP motif SITE: 181-257 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S308} alanine-rich region {315-324} MOTIF: alanine residue (SEVERAL) RNP motif NAME: RNP motif SITE: 338-412 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif RNP motif NAME: RNP motif SITE: 455-529 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif heterogeneous nuclear ribonucleoprotein H COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl RNP motif NAME: RNP motif SITE: 11-90 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S23} Ser phosphorylation site {S63} Thr phosphorylation site {T100} Ser phosphorylation site {S104} Thr phosphorylation site {T107} RNP motif NAME: RNP motif SITE: 111-188 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif domain {234-433} MOTIF: consensus repeat {234-249} Tyr phosphorylation site {Y246} RNP motif NAME: RNP motif SITE: 289-364 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Tyr phosphorylation site {Y306} Ser phosphorylation site {S310} consensus repeat {354-392} consensus repeat {354-372} consensus repeat {374-392} consensus repeat {418-433}

References

UniProt :accession Q92945

Components

far upstream element-binding protein 2; FUSE-binding protein 2; KH type-splicing regulatory protein; KSRP; p75 (KHSRP, FUBP2) heterogeneous nuclear ribonucleoprotein H; hnRNP H; contains: heterogeneous nuclear ribonucleoprotein H, N-terminally processed (HNRNPH1, HNRPH, HNRPH1) polypyrimidine tract-binding protein 1; PTB; heterogeneous nuclear ribonucleoprotein I; hnRNP I; 57 kD RNA-binding protein PPTB-1 (PTBP1, PTB) polypyrimidine tract-binding protein 2 (neurally-enriched homolog of PTB, neural polypyrimidine tract-binding protein, PTB-like protein, PTBP2, NPTB, PTB, PTBLP)

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