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fructose-1,6 diphosphate aldolase or fructose diphosphate aldolase
Classification:
- in vertebrates, 3 forms of are found
a) aldolase-A in muscle
b) aldolase-B in liver
c) aldolase-C in brain
Function:
- ubiquitous glycolytic enzyme
- splits D-fructose-1,6-diphosphate to: D-glyceraldehyde-3-phosphate + dihydroxyacetone-phosphate
Structure:
- tetramer
Expression:
- the most common isozyme pattern consists of varying proportions of a 5-membered set in which 2 members correspond to aldolase A & aldolase B homotetramers
- in brain, aldolase-C is expressed so that tetramers of aldolase-A, aldolase-C & 3 aldolase-A/C heterotetramers are found
Genetics:
- subunits determined by 3 separate gene loci
- only 2 of these loci, those producing Aldolase-A & aldolase-B appear to be active simultaneously in most tissues
Comparative biology:
- class-II aldolases found mainly in prokaryotes & fungi, are homodimeric enzymes requiring a divalent metal ion (generally Zn+2) for their activity
Interactions
molecular events
Related
fructose-1,6-diphosphate aldolase in serum
gluconeogenesis
glycolytic pathway (glycolysis, Embden Myerhof pathway)
Specific
aldolase-A (muscle-type aldolase, lung cancer antigen NY-LU-1, ALDOA, ALDA)
aldolase-B (liver-type aldolase, ALDOB, ALDB)
aldolase-C (brain-type aldolase, ALDOC, ALDC)
General
aldehyde lyase (aldolase)
glycolytic enzyme
oligomerizing protein
Properties
CONFIGURATION: tetramer
COMPARTMENT: cytoplasm
MOTIF: active site
MOTIF: lysine residue
Database Correlations
ENZYME 4.1.2.13
References
- Tietz Fundamentals of Clinical Chemistry 3rd ed, WB
Saunders, 1987 pg 412
- Stryer Biochemistry WH Freeman & Co, New York,
1988 pg 357