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fructose
In nutrition: Found in high-fructose corn syrup
Mechanism of action:
- intake correlates inversely with LDL particle size
- does not stimulate release of insulin or leptin
- may promote weight gain by not effectively inducing satiety [2]
- ingestion of fructose results in differences in blood flow (relative to glucose) in brain areas associated with hunger & reward (hypothalamus, thalamus, insula, cingulate cortex, fusiform gyrus, & striatum) [2]
- only sugar that raises serum uric acid
Interactions
molecular events
Related
high-fructose corn syrup
Specific
fructose phosphate
General
hexose
ketose
metabolic agent (metabolic modifier)
Properties
Database Correlations
PUBCHEM correlations
Kegg map/map00051
References
- Johnson RJ et al,
Potential role sugar (fructose) in the epidemic of
hypertension, obesity and the metabolic syndrome, diabetes,
and cardiovascular disease.
Am J Clin Nutr 2007, 86:899
PMID: 17921363
- Aeberli I et al,
Fructose intake is a predictor of LDL particle size in
overweight schoolchildren.
Am J Clin Nutr 2007, 86:1174
PMID: 17921399
- Bray GA
How bad is fructose?
Am J Clin Nutr 2007, 86:895
PMID: 17921361
- Page KA et al.
Effects of fructose vs glucose on regional cerebral blood flow
in brain regions involved with appetite and reward pathways.
JAMA 2013 Jan 2; 309:63.
PMID: 23280226
Substructure-of
sucrose
Component-of
citrate/fructose/glucose
FODMAP (Fermentable, Oligo-, Di-, Monosaccharides, & Polyols)
fructose/glucose
fructose/glucose/phosphoric acid