frizzled-9; Fz-9; hFz9; FzE6; CD349 (FZD9, FZD3)

Function: - receptor for Wnt proteins - most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin & activation of Wnt target genes - a second signaling pathway involving PKC & Ca⁺² fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase - both pathways seem to involve interactions with G-proteins - may be involved in transduction & intercellular transmission of polarity information during tissue morphogenesis &/or in differentiated tissues Structure: - Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (putative) - FZ domain is involved in binding with Wnt ligands - belongs to the G-protein coupled receptor Fz/smo family - contains 1 FZ (frizzled) domain Compartment: - cell membrane Expression: - expressed predominantly in adult & fetal brain, testis, eye, skeletal muscle & kidney - moderately expressed in pancreas, thyroid, adrenal cortex, small intestine & stomach. detected in fetal liver & kidney Pathology: - reference to Williams syndrome encountered (no verification) Note: - first described as FZD3 in literature

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen frizzled homolog protein glycoprotein

Properties

SIZE: entity length = 591 aa MW = 64 kD COMPARTMENT: plasma membrane MOTIF: exoplasmic domain {1-229} MOTIF: signal sequence {1-22} frizzled domain {34-155} cysteine residue {C39} MODIFICATION: cysteine residue {C100} cysteine residue {C47} MODIFICATION: cysteine residue {C93} N-glycosylation site {N53} cysteine residue {C84} MODIFICATION: cysteine residue {C122} cysteine residue {C93} MODIFICATION: cysteine residue {C47} cysteine residue {C100} MODIFICATION: cysteine residue {C39} cysteine residue {C111} MODIFICATION: cysteine residue {C152} cysteine residue {C115} MODIFICATION: cysteine residue {C139} cysteine residue {C122} MODIFICATION: cysteine residue {C84} cysteine residue {C139} MODIFICATION: cysteine residue {C115} cysteine residue {C152} MODIFICATION: cysteine residue {C111} N-glycosylation site {N158} transmembrane domain {230-250} cytoplasmic loop {251-266} transmembrane domain {267-287} exoplasmic loop {288-315} transmembrane domain {316-336} cytoplasmic loop {337-355} transmembrane domain {356-376} exoplasmic loop {377-400} transmembrane domain {401-421} cytoplasmic loop {422-447} transmembrane domain {448-468} exoplasmic loop {469-508} transmembrane domain {509-529} cytoplasmic domain {530-591} MOTIF: Lys-Thr-X-X-X-Trp {532-537}

Database Correlations

OMIM 601766 UniProt O00144 PFAM correlations Entrez Gene 8326 Kegg hsa:8326