frizzled-7; Fz-7; hFz7; FzE3 (FZD7)

Function: - receptor for Wnt proteins - most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin & activation of Wnt target genes - a second signaling pathway involving PKC & Ca⁺² fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase - both pathways seem to involve interactions with G-proteins - may be involved in transduction & intercellular transmission of polarity information during tissue morphogenesis &/or in differentiated tissues - interacts with MAGI3 (putative) Structure: - Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (putative) - FZ domain is involved in binding with Wnt ligands - belongs to the G-protein coupled receptor Fz/smo family - contains 1 FZ (frizzled) domain Compartment: - membrane Expression: - expressed in adult skeletal muscle & fetal kidney > fetal lung, adult heart, brain, & placenta Pathology: - specifically expressed in squamous cell esophageal carcinomas

General

frizzled homolog protein glycoprotein

Properties

SIZE: entity length = 574 aa MW = 64 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-256} MOTIF: signal sequence {1-32} frizzled domain {44-163} cysteine residue {C49} MODIFICATION: cysteine residue {C110} cysteine residue {C57} MODIFICATION: cysteine residue {C103} N-glycosylation site {N63} cysteine residue {C94} MODIFICATION: cysteine residue {C131} cysteine residue {C103} MODIFICATION: cysteine residue {C57} cysteine residue {C110} MODIFICATION: cysteine residue {C49} cysteine residue {C120} MODIFICATION: cysteine residue {C160} cysteine residue {C124} MODIFICATION: cysteine residue {C148} cysteine residue {C131} MODIFICATION: cysteine residue {C94} cysteine residue {C148} MODIFICATION: cysteine residue {C124} cysteine residue {C160} MODIFICATION: cysteine residue {C120} N-glycosylation site {N164} transmembrane domain {257-277} cytoplasmic loop {278-288} transmembrane domain {289-309} exoplasmic loop {310-336} transmembrane domain {337-357} cytoplasmic loop {358-379} transmembrane domain {380-400} exoplasmic loop {401-423} transmembrane domain {424-444} cytoplasmic loop {445-470} transmembrane domain {471-491} exoplasmic loop {492-528} transmembrane domain {529-549} cytoplasmic domain {550-574} MOTIF: Lys-Thr-X-X-X-Trp {552-557} PDZ recognition motif NAME: PDZ recognition motif SITE: 572-574 FOR-BINDING-VIA: PDZ domain

Database Correlations

OMIM 603410 UniProt O75084 PFAM correlations Entrez Gene 8324 Kegg hsa:8324