Frizzled-6; Fz-6; hFz6 (FZD6)

Function: - receptor for Wnt proteins - most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin & activation of Wnt target genes - a second signaling pathway involving PKC & Ca⁺² fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase - both pathways seem to involve interactions with G-proteins - may be involved in transduction & intercellular transmission of polarity information during tissue morphogenesis &/or in differentiated tissues Structure: - Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (putative) - FZ domain is involved in binding with Wnt ligands - belongs to the G-protein coupled receptor Fz/smo family - contains 1 FZ (frizzled) domain Compartment: - membrane Expression: - detected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus, prostate, testis, ovary, small intestine & colon - in the fetus, expressed in brain, lung, liver & kidney

General

frizzled homolog protein glycoprotein phosphoprotein

Properties

SIZE: entity length = 706 aa MW = 79 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-201} MOTIF: signal sequence {1-18} frizzled domain {19-132} cysteine residue {C24} MODIFICATION: cysteine residue {C85} cysteine residue {C32} MODIFICATION: cysteine residue {C78} N-glycosylation site {N38} cysteine residue {C69} MODIFICATION: cysteine residue {C106} cysteine residue {C78} MODIFICATION: cysteine residue {C32} cysteine residue {C85} MODIFICATION: cysteine residue {C24} cysteine residue {C95} MODIFICATION: cysteine residue {C129} cysteine residue {C99} MODIFICATION: cysteine residue {C123} cysteine residue {C106} MODIFICATION: cysteine residue {C69} cysteine residue {C123} MODIFICATION: cysteine residue {C99} cysteine residue {C129} MODIFICATION: cysteine residue {C95} transmembrane domain {202-222} cytoplasmic loop {223-233} transmembrane domain {234-254} exoplasmic loop {255-284} transmembrane domain {285-305} cytoplasmic loop {306-324} transmembrane domain {325-345} exoplasmic loop {346-370} MOTIF: N-glycosylation site {N352} transmembrane domain {371-391} cytoplasmic loop {392-416} transmembrane domain {417-437} exoplasmic loop {438-473} transmembrane domain {474-494} cytoplasmic domain {495-706} MOTIF: Lys-Thr-X-X-X-Trp {498-503} Ser phosphorylation site {S606} Thr phosphorylation site {T607}

Database Correlations

OMIM 603409 UniProt O60353 PFAM correlations Entrez Gene 8323 Kegg hsa:8323