frizzled-5; Fz-5; hFz5; FzE5 (FZD5)

Function: - receptor for Wnt proteins - most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin & activation of Wnt target genes - a second signaling pathway involving PKC & Ca⁺² fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase - both pathways seem to involve interactions with G-proteins - may be involved in transduction & intercellular transmission of polarity information during tissue morphogenesis &/or in differentiated tissues - receptor for Wnt5A ligand - interacts specifically with Wnt5A to induce the beta- catenin pathway - interacts with GOPC (putative) Structure: - PDZ-binding motif mediates interaction with GOPC - Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (putative) - FZ domain is involved in binding with Wnt ligands - belongs to the G-protein coupled receptor Fz/smo family - contains 1 FZ (frizzled) domain Compartment: - cell membrane, Golgi membrane - localized at the plasma membrane; also found at the Golgi (putative)

General

frizzled homolog protein glycoprotein

Properties

SIZE: entity length = 585 aa MW = 65 kD COMPARTMENT: golgi MOTIF: exoplasmic domain {1-238} MOTIF: signal sequence {1-26} frizzled domain {28-150} cysteine residue {C33} MODIFICATION: cysteine residue {C94} cysteine residue {C41} MODIFICATION: cysteine residue {C87} N-glycosylation site {N47} cysteine residue {C78} MODIFICATION: cysteine residue {C116} cysteine residue {C87} MODIFICATION: cysteine residue {C41} cysteine residue {C94} MODIFICATION: cysteine residue {C33} cysteine residue {C105} MODIFICATION: cysteine residue {C147} cysteine residue {C109} MODIFICATION: cysteine residue {C133} cysteine residue {C116} MODIFICATION: cysteine residue {C78} cysteine residue {C133} MODIFICATION: cysteine residue {C109} cysteine residue {C147} MODIFICATION: cysteine residue {C105} N-glycosylation site {N151} transmembrane domain {239-259} cytoplasmic loop {260-270} transmembrane domain {271-291} exoplasmic loop {292-315} transmembrane domain {316-336} cytoplasmic loop {337-358} transmembrane domain {359-379} exoplasmic loop {380-402} transmembrane domain {403-423} cytoplasmic loop {424-449} transmembrane domain {450-470} exoplasmic loop {471-500} transmembrane domain {501-521} cytoplasmic domain {522-585} MOTIF: Lys-Thr-X-X-X-Trp {525-530} PDZ recognition motif NAME: PDZ recognition motif SITE: 583-585 FOR-BINDING-VIA: PDZ domain

Database Correlations

OMIM 601723 UniProt Q13467 PFAM correlations Entrez Gene 7855 Kegg hsa:7855