Frizzled-3; Fz-3; hFz3 (FZD3)

Function: - receptor for Wnt proteins - most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin & activation of Wnt target genes - a second signaling pathway involving PKC & Ca⁺² fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase - both pathways seem to involve interactions with G-proteins - may be involved in transduction & intercellular transmission of polarity information during tissue morphogenesis &/or in differentiated tissues - interacts with VANGL2 (putative) Structure: - Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (putative) - FZ domain is involved in binding with Wnt ligands - belongs to the G-protein coupled receptor Fz/smo family - contains 1 FZ (frizzled) domain Compartment: - membrane Alternative splicing: - named isoforms=2; long, short Expression: - widely expressed - relatively high expression in a) CNS, including regions of the limbic system, b) kidney c) pancreas d) skeletal muscle e) uterus f) testis

General

frizzled homolog protein glycoprotein

Properties

SIZE: entity length = 666 aa MW = 76 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-205} MOTIF: signal sequence {1-22} frizzled domain {23-136} cysteine residue {C28} MODIFICATION: cysteine residue {C89} cysteine residue {C36} MODIFICATION: cysteine residue {C82} N-glycosylation site {N42} cysteine residue {C73} MODIFICATION: cysteine residue {C110} cysteine residue {C82} MODIFICATION: cysteine residue {C36} cysteine residue {C89} MODIFICATION: cysteine residue {C28} cysteine residue {C99} MODIFICATION: cysteine residue {C133} cysteine residue {C103} MODIFICATION: cysteine residue {C127} cysteine residue {C110} MODIFICATION: cysteine residue {C73} cysteine residue {C127} MODIFICATION: cysteine residue {C103} cysteine residue {C133} MODIFICATION: cysteine residue {C99} transmembrane domain {206-226} cytoplasmic loop {227-237} transmembrane domain {238-258} exoplasmic loop {259-288} MOTIF: N-glycosylation site {N265} transmembrane domain {289-309} cytoplasmic loop {310-328} transmembrane domain {329-349} exoplasmic loop {350-374} MOTIF: N-glycosylation site {N356} transmembrane domain {375-395} cytoplasmic loop {396-420} transmembrane domain {421-441} exoplasmic loop {442-477} transmembrane domain {478-498} cytoplasmic domain {499-666} MOTIF: Lys-Thr-X-X-X-Trp {502-507}

Database Correlations

OMIM 606143 UniProt Q9NPG1 PFAM correlations Entrez Gene 7976 Kegg hsa:7976